A plea was filed by the Quaid-e-Azam Mazar Management Board to register a case against the PML-N leaders, party workers
Pakistan News
Startups
Allozymes looks to upend chemical manufacturing with rapid enzyme engineering and $5M seed
July 6, 2021Part of the complex process that turns raw materials into finished products like detergents, cosmetics and flavors relies on enzymes, which facilitate chemical transformations. But finding the right enzyme for a new or proposed drug or additive is a drawn out and almost random process — which Allozymes aims to change with a remarkable new system that could set a new standard in the industry, and has raised a $5M seed round to commercialize.
Enzymes are chains of amino acids, the “building blocks of life” among of the many things encoded in DNA. These large, complex molecules bind to other substances in a way that facilitates a chemical reaction, say turning sugars in a cell into a more usable form of energy.
One also finds enzymes in the world of manufacturing, where major companies have identified and isolated enzymes that perform valuable work like taking some cheap base ingredients and making them combine into a more useful form. Any company that sells or needs lots of any particular chemical that doesn’t appear abundantly in nature probably has enzymatic processes to aid in creating more of it.
But it’s not like there’s just an enzyme for everything. When you’re inventing new molecules from scratch, like a novel drug or flavoring, there’s no reason why there should be a naturally occurring enzyme that reacts with or creates it. No animal synthesizes allergy medicine in its cells. So companies must find or create new enzymes that do what’s needed. The problem is that enzymes are generally at least 100 units long, and there are 20 amino acids to choose from, meaning for even the simplest novel enzyme you’re looking at uncountably numerous variations.
By starting with known enzymes and systematically working through variations that seem intuitively like they might work, researchers have been able to find new and useful enzymes, but the process is complex and slow even when fully automated: at most a couple hundred a day, and that’s if you happen to have a top-of-the-line robotic lab.
So when Allozymes comes in with a claim that it can screen up to ten million per day, you can imagine the level of change that represents.
Allozymes was founded by Peyman Salehian (CEO) and Akbar Vahidi (CTO), two Iranian chemical engineers who met while pursuing their PhDs at the National University of Singapore. The three years of research leading up to the commercial product also occurred at NUS, which holds the patent and exclusively licenses it to the company.
“The state of the art hasn’t changed in 20 years,” said Salehian. “When we talk with GSK, Pfizer, Merck, they have whole departments for this, they have $2 million robots, and it still takes a year to get a new enzyme.”
The Allozymes platform will speed up the process by several orders of magnitude, while decreasing the cost by an order of magnitude, Salehian said. If these estimates bear out, it effectively trivializes the enzyme search and obsoletes billions in investments and infrastructure. Why pay more to get less?
Traditionally, enzymes are isolated and selected over a multi-step process that involves introducing DNA templates into cells, which are cultured to create the target enzymes, which once a certain growth state is achieved, are analyzed robotically. If there are promising results, you go down that road with more variations, otherwise start again from the beginning. There’s a lot of picking and placing little dishes, waiting for enough cells to produce enough of the stuff, and so on.
The process Salehian and Vahidi designed is fully contained with a little benchtop device the size of a microwave, and generates almost no waste. Instead of using culture dishes, the device puts the necessary cells, substrate, and other ingredients in a tiny droplet in a microfluidic system. The reactions occur inside this little drop, which is incubated, tracked, and eventually collected and tested in a fraction of the time a larger sample would take.
Allozymes isn’t selling the device, though. It’s enzyme engineering as a service, and for now their partners and customers seem content with that. Its primary service is cut-to-size, depending on the needs of the project. For instance, maybe a company has a working enzyme already and just wants a variant that’s easier to synthesize or less dependent on certain expensive additives. With a solid starting point and flexible goal that might be a project on the smaller side. Another company may be looking to completely replace hard chemistry processes in their manufacturing, know the start and the end of the process but need an enzyme to fill in the gaps; that might be a more wide ranging and expensive project.
Vahidi explained that the goal is not to “democratize” enzyme engineering. It’s still expensive and large-scale enough that it will primarily be done by large companies, but now they can get a hundred thousand times more out of their R&D dollar. The speed and value put them above the competition, said Sahelian, with companies like Codexis, Arzeda, and Ginkgo Bioworks also doing enzyme bioengineering but at lower rates and with different priorities.
Occasionally the company might strike a bargain to take part ownership of an IP or product, but that’s not really the business model, Sahelian said. Some early work consisted of actually making the final compound, but ultimately the core product is expected to be the service. (Still, a million-dollar order is nothing to sneeze at.)
It may have occurred to you that in the process of doing a job, Allozymes might sort through hundreds of millions of enzymes. Rest assured, they are well aware of the value these may represent. The service transitions seamlessly into the inevitable data play.
“If you have a big data set that shows ‘if you change this amino acid this will be the function,’ you don’t even need to engineer it, you can eliminate it [i.e. from consideration]. You can even design enzymes if you know enough,” Salehian said.
The company’s recent $5M seed round was led by SOSV and Temasek, Singapore’s sovereign fund. Salehian explained that they planned to incorporate in the U.S. following interest from American venture firms, but Temasek’s early stage investor convinced them to stay.
“Biotransformation is in huge demand on this side of the world,” Salehian said. “Chemical, agriculture, and food companies need to do it, but no platform company can deliver these services. So we tried to fill that gap.”
Pakistan News
Govt working on holding talks with disgruntled Baloch leaders not associated with India: Fawad
July 6, 2021Balochistan will soon be a “cradle of peace” in the country, the minister says
Audacity is hugely popular audio editing software, often used by beginner podcasters but with some powerful features, despite its free, open-source status.
However, recent changes to Audacity’s privacy policy have led to accusations that the editing app is now spyware. Alongside collecting user data for “app analytics” and “improving our app” — typical stuff — the data will also apparently be used for “legal enforcement.”
Engadget
The policy says it will capture “data necessary for law enforcement, litigation and authorities’ requests (if any).” It may share personal data with “any competent law enforcement body, regulatory, government agency, court or other third party where we believe disclosure is necessary.” Yes, it’s a little vague.
These privacy policy changes follow Audacity’s acquisition by Muse Group back in April. The changes also include a ban on under-13s using Audacity, which would violate the license under which the software is currently distributed.
Data collection was apparently in the planning since Audacity’s purchase. As some reports have noticed, a Github update says the app was supposed to include opt-in anonymous analytics data collection, handled through Google and Yandex, but this was caveated by remarks that it would be “strictly optional and disabled by default.” It didn’t sound as broad as the eventual policy update.
Talking of Github, some users are already calling for a fork of the software, creating a new version of the app based on the source code. For Audacity owners, Muse Group, it’s a rough start to its newest purchase.
— Mat Smith
Final Fantasy VII Remake Intergrade’s entertaining DLC should also be on PS4
It lightly taps into the possibilities of the PS5.
Square Enix
Final Fantasy 7 Remake Intergrade is a little confusing, if the name didn’t give it away. It’s Final Fantasy 7 Remake polished up for the PlayStation 5, but it also includes new original content called Intermission. This is a two-chapter run completely separate to the main game, following the once-optional character Yuffie arriving into Remake’s main locale, Midgar. Sadly, you can only play Intermission with a PS5. But, oh boy, it plays like a dream. Continue reading.
Bugatti joins forces with electric hypercar maker Rimac
It’s a joint venture with Porsche called Bugatti Rimac.
Bugatti/Rimac
Electric hypercar company Rimac is taking control of Volkswagen’s supercar brand Bugatti as part of a joint venture with Porsche (which VW owns). Bugatti and Rimac will share resources and expertise but remain separate brands with their own production and distribution setups.
Bugatti will be able to harness Rimac’s EV know-how and perhaps carry on its legacy of making electric vehicles. Rimac, meanwhile, can tap into the knowledge of Bugatti, which makes the second-fastest street-legal car on the planet: the Bugatti Veyron. Continue reading.
A nanofiber membrane could help solve the drinking water crisis
The filter makes sea water drinkable in minutes.
Korean scientists claim a new desalination technique makes seawater fit to drink in minutes. The researchers’ membrane distillation process resulted in 99.9 percent salt rejection for a whole month. If commercialized, they say the solution could help alleviate the drinking water crisis exacerbated by climate change. According to the UN, more than 3 billion people worldwide are affected by water shortages.
While scientists have used membrane distillation in the past, if the membrane became too wet, it was unable to reject the salt. This particular solution uses a 3D membrane and nanotechnology. Continue reading.
Bumble is opening a restaurant to help people date IRL again
Bringing us back, kicking and screaming, into the dating game.
Bumble/Float Studio
In New York, Bumble is opening a café/restaurant/wine bar. Bumble Brew is scheduled to open for breakfast service on July 24th, with lunch and dinner service starting at the Nolita spot in the coming weeks. Along with an 80-seat dining room, there will be a cocktail bar, patio dining and private dining space.
The new venture builds on the Bumble Hive pop-up community spaces where people can hang out, eat and drink and meet others. Alas, you won’t be able to reserve a table direct from the app — at least not yet. Continue reading.
But wait, there’s more…
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OnePlus Nord N200 5G review: A $240 5G phone that’s predictably average
Researchers retrofit microscopes to take 3D images of cells in real time
Post-pandemic gas revival may threaten climate change targets
Facebook, Google and Twitter threaten to leave Hong Kong over privacy law changes
Reviews and Gadgets
Atari steps back from mobile games to focus on ‘premium’ PC and console titles
July 6, 2021As part of its latest turnaround strategy, Atari is shifting its focus away from free-to-play mobile games to PC and console titles. In a statement released on Monday, the company said its board of directors had approved the new plan on July 1st after conducting an in-depth review of the Atari Gaming division’s “assets and opportunities.”
The reorientation comes less than a month after the release of the oft-delayedAtari VCS console, which acts as both a retro gaming machine and PC. Atari said it would reach into its its portfolio of 200 games and franchises — think Asteroids, Centipede, Missile Command and Pong — to create new content for the VCS and other platforms. The first new releases are expected to arrive in the current fiscal year, which ends March 31st, 2022.
At the same time, the reinvention spells trouble for some of its mobile games, several of which it plans to shutdown or sell off. Impacted titles include Roller Coaster Tycoon Stories, Crystal Castles, Castles & Catapults, Ninja Golf and Atari Combat: Tank Fury. Despite decrying the competitive nature of the free-to-play gaming market, the company isn’t giving up on those titles it deems successful. More broadly, it’s taking a more shrewd approach to free-to-play fare after diving into mobile games, along with MMOs, in conjunction with its turnaround plan in 2015.
In addition, the company is also exiting its online Atari Casino in Africa — a social gambling play that included retro gaming-themed slots, poker and blackjack — and writing down its TV show assets with a renewed focus on licensing agreements.
Reviews and Gadgets
Animal Crossing, Mario and Pokémon Switch games drop to all-time lows
July 6, 2021If you have somehow not jumped on the Animal Crossing bandwagon yet, now’s your chance to do so for less. Amazon and Best Buy have the popular Nintendo Switch title for $45, or $15 off its normal price. It’s also a new low since we’ve only seen the game drop to $50 in the past. The only caveat is that the sale is only on the physical version of the game, not the digital download.
Buy Animal Crossing: New Horizons at Amazon – $45Buy Animal Crossing: New Horizons at Best Buy – $45
New Horizons came out in March 2020, which meant millions of players found an escape from the pandemic in its adorable animations, pleasant music, ASMR-like sound effects and its open-island gameplay. You’re tasked with building your personal island from the ground up with seemingly endless customizations, while you spend your days fishing, catching bugs, making friends with your neighbors and more. And with online multiplayer mode, you can visit your friends’ islands at your leisure.
If you’ve already devoted countless hours into your Animal Crossing island, there are a bunch of other Switch games on sale right now as well. Super Mario 3D World + Bower’s Fury, Super Mario 3D All-Stars, Super Smash Bros. Ultimate and Pokémon Snap are all down to $45. That’s a record-low price for all of those titles, so it’s a good time to stock up on new games if you’ve been waiting for a decent sale.
Buy Super Mario 3D World at Amazon – $45Buy Super Mario 3D World at Best Buy – $45
Buy Super Smash Bros. Ultimate at Amazon – $45Buy Super Smash Bros. Ultimate at Best Buy – $45
Buy Super Mario 3D All-Stars at Best Buy – $45Buy Pokémon Snap at Best Buy – $45
Follow @EngadgetDeals on Twitter for the latest tech deals and buying advice.
Four years after unleashing the Switch upon the world, Nintendo is releasing an upgraded version of its phenomenally successful console. After years of rumors, the company has at last confirmed the existence of a new Switch model with an OLED display. It’ll cost $349.99 and arrive on October 8th.
As expected, the latest model has a larger, seven-inch screen. The 720p OLED display, which Nintendo claims is more vivid, is a step up from the 6.2-inch LCD screen on the original Switch. The console has significantly reduced bezels and 64GB of storage, while the dock has a wired LAN port.
Nintendo is promising “enhanced audio” with the new Switch, which works with all existing Joy-Con controllers. The company is offering it in the traditional neon red/blue color scheme with a black dock, or in a white/black color scheme with a white dock.
The new Switch also has what looks like a massively improved kickstand that spans the entire width of the back of the console. It can be propped up at any angle and looks far sturdier than the tiny, fragile piece of plastic that propped up the old Switch.
However, there’s no 4K output, as reports had widely suggested. You’ll still only play at a maximum resolution of 1080p in docked mode. Nor has Nintendo said it will upgrade any other parts of the Switch. The OLED device was rumored to use NVIDIA’s DLSS tech with an upgraded chip. The company also warned that tweaks such as the larger screen mean the new Switch might not work as neatly with Nintendo Labo products.
The original Switch is still selling like hot cakes, so there’s a case to be made that Nintendo didn’t need to upgrade the console just yet. But the original Switch’s display and huge bezels are starting to look a little bit dated in 2021; this OLED screen should modernize the experience significantly. That said, for people who want to save some cash, Nintendo will continue selling the original Switch, at least for now.
It’s highly likely that demand will far exceed supply. Nintendo president Shuntaro Furukawa told investors in a call in May that the company was still contending with shortages and production issues. The current global scarcity of semiconductors will also limit production capacity. So, the new Switch might be even harder to find than the current console has been at various points.
Since it released the original Switch in 2017, Nintendo has issued a revised model with a battery upgrade. It also released the handheld-only Switch Lite in 2019. Two years later, moving in the other direction with an upgraded Switch is a logical move. Good luck getting your hands on one any time soon, though.
Nothing is borrowing a strategy from its founder Carl Pei’s previous gig at OnePlus: dribbling technical details ahead of a product launch. The startup has revealed that its Ear 1 true wireless earbuds will include three-microphone active noise cancellation at a price of $99 (£99). That’s not dramatically more affordable than value-for-money rivals like Amazon’s second-gen Echo Buds, but it’s certainly low enough to get your attention if you’re cost-conscious.
The company will formally unveil the Ear 1 at a launch event on July 27th. To date, the buds are known to include a partially transparent Teenage Engineering design and will boast “leading specs,” although it’s not clear what that entails beyond ANC.
The challenge, as you might guess, is delivering quality that matches the hype. ANC will help isolate music and podcasts, but it won’t matter as much if the sound quality is merely so-so. Nothing will have to show that it can deliver solid sound at its asking price, particularly if it’s going to compete against the likes of the Echo Buds or Google’s Pixel Buds A.
Google came out with the latest version of the Nest Thermostat at the end of last year. While it was already a tempting gadget for those looking to save energy and make their homes smarter, Google sweetened the deal by pricing the thermostat at $130. It has since gone on sale a few times, but today you can grab the snow color option for $88, which is 32 percent off its normal price and a record low. Also, the snow Thermostat with a Trim Kit is on sale for $103, or $12 less than the other Trim Kit packages. Other colors are down to $100, which is the same sale price we saw back in April around Earth Day.
Buy Nest Thermostat at Amazon – $88Buy Nest Thermostat + Trim Kit at Amazon – $103
Compared to previous Nest thermostats, this one is slimmer, has a touch-sensitive edge and a mirrored display that both looks lovely and automatically wakes up when you approach it. In addition to looking better than most conventional thermostats, the Nest Thermostat is much smarter as well, allowing you to control via on-device controls, Google’s Home app and even with Assistant or Alexa voice commands. The device itself has a redesigned controller view too, which makes it easier to quickly set the temperature in your home.
But the automatic features are likely the biggest selling points for a device like the Nest Thermostat. It recognizes when you’ve left your home and will automatically go into Eco mode, keeping your home at a specific temperature until you return when it will either raise or lower the temperature based on your preferences. This Nest Thermostat also has Savings Finder, a feature that continuously looks for ways to reduce your energy bill throughout the year. For example, the device will suggest adjustments based on weather conditions — think reducing your home heat usage during a particularly warm winter — that you can choose to accept in order to potentially decrease your energy costs. Although a smart thermostat like Nest’s takes a bit more installation that a standard smart light bulb, it’s a good entry point into the smart home world — and it’s even better when on sale like this.
Follow @EngadgetDeals on Twitter for the latest tech deals and buying advice.
Reviews and Gadgets
Batters in the Home Run Derby will livestream using 5G helmet cameras
July 6, 2021If you’ve ever wanted to see a pro baseball player’s at-bat through their eyes, you’re about to get your chance. T-Mobile is marketing its 5G network by equipping players at the 2021 Home Run Derby with 5G point-of-view cameras on their helmets, including the catchers’ masks. Watch the live competition through a special T-Mobile website and you can witness both batting practice and the derby itself as if you were on the field, with 5G (hopefully) keeping everything in sync.
The event kicks off July 12th, starting with practice at 6:30PM Eastern and the derby itself at 8PM. The POV cameras are also coming alongside a new MLB AR mobile app to explore Coors Field in 3D and get detailed stats for each swing. People with 5G phones will also get extra stats like hang time and exit velocity, although this is clearly just an incentive to upgrade your device. You don’t need 5G to get a few extra numbers.
The footage is ‘only’ in HD, and it’s not clear just how many players will have 5G cameras (we’ve asked T-Mobile for details). If all goes well, though, you’ll see what it’s like for stars like Shohei Ohtani when they knock one out of the park. Look at it this way — even if the cameras are limited, this is one of the few 5G tie-ins that’s more than just a gimmick.